Chapter 1. What Is Molecular and Cellular Imaging? .............. 1
Michel M.J. Modo and Jeff W.M. Bulte
PART I Contrast Agents for Molecular and Cellular Imaging
Chapter 2. Physicochemical Principles of MR Contrast
Agents .............................................. 13
Peter Caravan
Chapter 3. Paramagnetic Contrast Agents ........................ 37
Silvio Aime, Zsolt Baranyai, Eliana Gianolio,
and Enzo Terreno
Chapter 4. Superparamagnetic Contrast Agents ................... 59
Claire Corot, Marc Port, Irene Guilbert,
Philippe Robert, Isabelle Raynal, Caroline
Robic, Jean-Sebastien Raynaud, Philippe
Prigent, Anne Dencausse, and Jean-Marc Idee
Chapter 5. Physical Mechanism and Applications of CEST
Contrast Agents ..................................... 85
Michael T. McMahon, Jinyuan Zhou, Assaf A.
Gilad, Jeff W.M. Bulte, and Peter C.M. van
Zijl
Chapter 6. PARACEST Contrast Agents ........................... 101
A. Dean Sherry and Mark Woods
Chapter 7. Genetic Approaches for Modulating MRI Contrast ..... 123
Eric T. Ahrens, William F. Goins, and Clinton
S. Robison
PART II Molecular MR Imaging
Chapter 8. Molecular and Functional MR Imaging of Cancer ...... 141
Michael A. Jacobs, Kristine Glunde, Barjor
Gimi, Arvind P. Pathak, Ellen Ackerstaff,
Dmitri Artemov, and Zaver M. Bhujwalla
Chapter 9. Molecular Imaging of Atherosclerosis with
Magnetic Resonance ................................. 161
Karen C. Briley-Saebo, Willem J. Mulder,
Fabien Hyafil, Venkatesh Mani, Vardan
Amirhekian, Juan Gilherto S. Aguinaldo,
James F. Rudd, Silvia H. Aguiar, and Zahi
A. Fayad
Chapter 10.Molecular Imaging of Apoptosis ..................... 183
Mikko I. Kettunen and Kevin M. Bundle
Chapter 11.Molecular Imaging of Reporter Genes ................ 199
Keren Ziv, Dorit Granot, Vicki Plaks, Batya
Cohen, and Michal Neeman
Chapter 12.Pharmacological MRI as a Molecular Imaging
Technique .......................................... 219
Y. Iris Chen and Bruce G. Jenkins
PART III Cellular MR Imaging
Chapter 13.Cellular MR Imaging of the Liver Using Contrast
Agents ............................................. 247
N. Cem Balci and Sukru Mehmet Erturk
Chapter 14.Cellular Imaging of Macrophage Activity in
Infection and Inflammation ......................... 259
Martin Rausch, Markus Rudin, Peter R.
Allegrini, and Nicolau Beckmann
Chapter 15.Cellular Imaging of Macrophage Activity in
Stroke ............................................. 273
Ralph Weber and Mathias Hoehn
Chapter 16.Magnetic Resonance Imaging in Developmental
Biology ............................................ 283
Cyrus Papan, J. Michael Tyszka, and Russell
E. Jacobs
Chapter 17.Methods for Labeling Nonphagocytic Cells with
MR Contrast Agents ................................. 295
Joseph A. Frank, Stasia A. Anderson, and Ali
S. Arbab
Chapter 18.Cellular Imaging of Cell Transplants ............... 325
Michel M.J. Modo and Jeff W.M. Bulte
Chapter 19.Cellular and Molecular Imaging of the Diabetic
Pancreas ........................................... 343
Zdravka Medarova and Anna Moore
Chapter 20.Functional Cellular Imaging with Manganese ......... 369
Vincent Van Meir and Annemie Van der Linden
PART IV Future Perspectives for Molecular and Cellular Imaging
Chapter 21.Translating Promising Experimental Approaches
to Clinical Trials ................................. 395
Adrian D. Nunn
Chapter 22.An Outlook on Molecular and Cellular MR Imaging .... 405
Michel M.J. Modo and Jeff' W.M. Bulte
Index ......................................................... 411
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