Special Features ............................................. viii
Detailed Contents .............................................. ix
Acknowledgments .............................................. xxvi
A Note to the Reader ......................................... xxxi
PART I. INTRODUCTION TO THE CELL
1. Cells and Genomes ............................................ 1
2. Cell Chemistry and Biosynthesis ............................. 45
3. Proteins ................................................... 125
PART II. BASIC GENETIC MECHANISMS
4. DNA, Chromosomes, and Genomes .............................. 195
5. DNA Replication, Repair, and Recombination ................. 263
6. How Cells Read the Genome: From DNA to Protein ............. 329
7. Control of Gene Expression ................................. 411
PART III. METHODS
8. Manipulating Proteins, DNA, and RNA ........................ 501
9. Visualizing Cells .......................................... 579
PART IV. INTERNAL ORGANIZATION OF THE CELL
10.Membrane Structure ......................................... 617
11.Membrane Transport of Small Molecules and the Electrical
Properties of Membranes .................................... 651
12.Intracellular Compartments and Protein Sorting ............. 695
13.Intracellular Vesicular Traffic ............................ 749
14.Energy Conversion: Mitochondria and Chloroplasts ........... 813
15.Mechanisms of Cell Communication ........................... 879
16.The Cytoskeleton ........................................... 965
17.The Cell Cycle ............................................ 1053
18.Apoptosis ................................................. 1115
PART V. CELLS IN THEIR SOCIAL CONTEXT
19.Cell Junctions, Cell Adhesion, and the Extracellular
Matrix .................................................... 1131
20.Cancer .................................................... 1205
Chapters 21-25 available on Media DVD-ROM
21.Sexual Reproduction: Meiosis, Germ Cells, and
Fertilization ............................................. 1269
22.Development of Multicellular Organisms .................... 1305
23.Specialized Tissues, Stem Cells, and Tissue Renewal ....... 1417
24.Pathogens, Infection, and Innate Immunity ................. 1485
25.The Adaptive Immune System ................................ 1539
Glossary ...................................................... G-l
Index ......................................................... I-1
Tables The Genetic Code, Amino Acids .......................... T-l
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