Frontispiece
К.Frank Austen ............................................... x
Doing What I Like
K.Frank Austen ............................................... 1
Protein Tyrosine Phosphatases in Autoimmunity
Torkel Vang, Ana V.Miletic, Yutaka Arimura, Lutz
Tautz, Robert C.Rickert, and Tomas Mustelin ................. 29
Interleukin-21: Basic Biology and Implications
for Cancer and Autoimmunity
Rosanne Spolski and Warren J.Leonard ........................ 57
Forward Genetic Dissection of Immunity to Infection in
the Mouse
S.M.Vidal, D.Malo, J.-F.Marquis, and P.Gros ................. 81
Regulation and Functions of Blimp-1 in T and В Lymphocytes
Gislaine Martins and Kathryn Calame ........................ 133
Evolutionarily Conserved Amino Acids That Control TCR-MHC
Interaction
Philippa Marrack, James P.Scott-Browne, Shaodong Dai,
Laurent Gapin, and John W.Kappler .......................... 171
T Cell Trafficking in Allergic Asthma: The Ins and Outs
Benjamin D.Medoff, Seddon Y.Thomas, and Andrew
D.Luster ................................................... 205
The Actin Cytoskeleton in T Cell Activation
Janis K.Burkhardt, Fsteban Carrizosa, and Meredith
H.Shaffer .................................................. 233
Mechanism and Regulation of Class Switch Recombination
Janet Stavnezet; Jeroen E.J.Guikema, and
Carol E.Schrader ........................................... 261
Migration of Dendritic Cell Subsets and their Precursors
Gwendalyn J. Randolph, Jordi Ochando, Santiago Partida-
Sánchez .................................................... 293
The APOBEC3 Cytidine Deaminases: An Innate Defensive
Network Opposing Exogenous Retroviruses and
Endogenous Retroelements
Ya-Lin Chiu and Warner C.Greene ............................ 317
Thymus Organogenesis
Hans-Reimer Rodewald ....................................... 355
Death by a Thousand Cuts: Granzyme Pathways of Programmed
Cell Death
Dipanjan Chowdhury, Judy Lieberman ......................... 389
Monocyte-Mediated Defense Against Microbial Pathogens
Natalya V.Serbina, Ting Jia, Tobias M.Hohl, and Eric
G.Pamer .................................................... 421
The Biology of Interleukin-2
Thomas R.Makk .............................................. 453
The Biochemistry of Somatic Hypermutation
Jonathan U.Peled, Fei Li Kuang, Maria D.Iglesias-
Ussel, Sergio Roa, Susan L.Kalis, Myron F.Goodman, and
Matthew D.Scharff .......................................... 481
Anti-Inflammatory Actions of Intravenous Immunoglobulin
Falk Nimmerjahn and Jeffrey V.Ravetch ...................... 513
The IRF Family Transcription Factors in Immunity and
Oncogenesis
Tomohiko Tamura, Hideyuki Yanai, David Savitsky,
and Tadatsugu Taniguchi .................................... 535
Choreography of Cell Motility and Interaction Dynamics
Imaged by Two-Photon Microscopy in Lymphoid Organs
Michael D.Cahalan and Ian Parker ........................... 585
Development of Secondary Lymphoid Organs
Troy D.Randall, Damian M.Carragher, and
Javier Range T.Moreno ...................................... 627
Immunity to Citrullinated Proteins in Rheumatoid Arthritis
Lars Klareskog, Johan Rönnelid, Karin Lundberg,
Leonid Padyukov, and Lars Alfredsson ....................... 651
PD-1 and Its Ligands in Tolerance and Immunity
Mary E.Keir, Manish J.Butte, Gordon J.Freeman,
and Arlene H.Sharpe ........................................ 677
The Master Switch: The Role of Mast Cells in Autoimmunity
and Tolerance
Blayne A. Sayed, Alison Christy, Mary R. Quirion,
and Melissa A. Brown ....................................... 705
T Follicular Helper (ТFH) Cells in Normal and
Dysregulated Immune Responses
Cecile King, Stuart G.Tangye, and Charles R.Mackay ......... 741
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