The role of microtubules in cell biology, neurobiology, and oncology / ed. by Fojo T. - Totowa, N.J.: Humana Press. - 2008. - xviii, 587 p.: ill. + 1 CD-ROM. - (Cancer drug discovery and development) - ISBN 978-1-58829-294-0  Место хранения:   056 | Институт химической биологии и фундаментальной медицины CO РАН | Новосибирск| Библиотека

Оглавление / Contents

Preface ....................................................... vii Contributors ................................................... xi List of Color Plates ......................................... xiii 1. An Overview of Compounds That Interact with Tubulin and Their Effects on Microtubule Assembly .................... 1 Ernest Hamel 2. Molecular Mechanisms of Microtubule Acting Cancer Drugs ................................................ 21 John J.Correia and Sharon Lobert 3. Microtubule Dynamics: Mechanisms and Regulation by Microtubule-Associated Proteins and Drugs In Vitro and in Cells ................................................ 47 Mary Ann Jordan and Leslie Wilson 4. Microtubule Associated Proteins and Micro tubule- Interacting Proteins: Regulators of Microtubule Dynamics .................................................... 83 Maria Kavallaris, Sima Don, and Nicole M.Verrills 5. The Post-Translational Modifications of Tubulin ............ 105 Richard F.Luduena and Asok Banerjee 6. The Isotypes of Tubulin: Distribution and Functional Significance ................................ 123 Richard F.Luduena and Asok Banerjee 7. The Tubulin Superfamily .................................... 177 Richard F.Luduena and Asok Banerjee 8. Tubulin Proteomics in Cancer ............................... 193 Pascal Verdier-Pinard, Fang Wang, Ruth Hogue Angeletti, Susan Band Horwitz, and George A.Orr 9. Tubulin and Microtubule Structures ......................... 211 Eva Nogales and Kenneth H.Downing 10.Destabilizing Agents: Peptides and Depsipeptides ........... 227 Lee M.Greenberger and Frank Loganzo 11.Molecular Features of the Interaction of Colchicine and Related Structures with Tubulin ............. 259 Susan L.Bane 12.Antimicrotubule Agents That Bind Covalently to Tubulin ................................................. 281 Dan L.Sackett 13.Microtubule Stabilizing Agents ............................. 307 Susan Band Horwitz and Tito Fojo 14.Mechanisms of Resistance to Drugs That Interfere with Microtubule Assembly .................................. 337 Fernando Cabral 15.Resistance to Microtubule-Targeting Drugs .................. 357 Paraskevi Giannakakou and James P.Snyder 16.Microtubule Stabilizing Agents in Clinical Oncology: The Taxanes ...................................... 395 Chris H.Takimoto and Muralidhar Beeram 17.Investigational Anticancer Agents Targeting the Microtubule ............................................ 421 Lyudmila A.Vereshchagina, Orit Scharf, and A.Dimitrios Colevas 18.Microtubule Damaging Agents and Apoptosis .................. 479 Manon Carre and Diane Braguer 19.Microtubule Targeting Agents and the Tumor Vasculature .......................................... 519 Raffaella Giavazzi, Katiuscia Bonezzi, and Giulia Taraboletti 20.Neurodegenerative Diseases: Таи Proteins in Neurodegenerative Diseases Other Than AD ................... 531 André Delacourte, Nicolas Sergeant, and Luc Buée 21.Structure, Function, and Regulation of the Microtubule Associated Protein Tau ..................................... 559 Janis Bunker and Stuart C. Feinstein Index ......................................................... 577