Foreword ...................................................... vii
Acknowledgments ................................................ ix
Dedication ..................................................... xi
Preface ...................................................... xiii
Critical Compilation of pKa Values for Pharmaceutical Substances
Richard J. Prankerd
l Introduction ................................................. 1
2. Evaluation of Methods for pKa Determination .................. 7
3. pKa Values from Computer Programs ........................... 24
4. Summary of the Data Compilation ............................. 26
References ..................................................... 28
Data Compilations
Appendix A
Main List
pKa Values Found with Significant Data Quality Information-
Mainly Primary Literature ...................................... 35
Appendix B
Supplementary List
pKa Values Found with Little or No Data Quality
Information-Mainly Secondary Literature ....................... 425
Index
Alphabetical Index of Drugs or Drug Related Compounds
Found in pKa Database Files ................................... 627
Subject Index ................................................. 725
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