Lim H. Multiplicity yours: cloning, stem cell research, and regenerative medicine (Singapore, 2006). - ОГЛАВЛЕНИЕ / CONTENTS
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ОбложкаLim H. Multiplicity yours: cloning, stem cell research, and regenerative medicine. - Singapore: World Scientific Publications, 2006. - 412 p. - ISBN 981-265-866-2
 

Оглавление / Contents
 
Acknowledgments .............................................. xiii

Preface ...................................................... xvii

1 Prologue ...................................................... 1
  About the Title of the Book ................................... 1
  Risks of Writing this Book .................................... 3
  The Title Revisited ........................................... 6
    What Has Gravity Got To Do with This Book? .................. 7
    One-Handed Scientist ........................................ 9
    Information Cornucopia ..................................... 12
      Will the Y Chromosome Decay and Take Men with It? ........ 13
    A Goal of This Book ........................................ 15
  Inside This Book ............................................. 15
  Best Use of This Book ........................................ 19

2 A Primer on Genetics ......................................... 21
  Living Things ................................................ 21
  Tinkering Using Technology ................................... 24
  Survival of the Fittest ...................................... 27
    How Genetics Changed the Course of History ................. 29
  Timeline of Genetics ......................................... 30

3 Sex - A Primal Instinct ...................................... 37
  The Primal Instinct for Sex .................................. 37
    Emperor Penguins ........................................... 37
    Salmons .................................................... 39
    Pacific Grunions ........................................... 39
    Other Aspects of Sex ....................................... 40
    Sex Reigns - Birds and Bees Do It, But Why? ................ 41
  Models of Co-Evolution ....................................... 42
    The Deleterious Mutation Hypothesis ........................ 43
    The Red Queen Hypothesis ................................... 44
  Computer Simulations ......................................... 46
    Supporting Evidence ........................................ 47
    Scandal without Sex ........................................ 48
  Selfish Genes ................................................ 49
    Selfishly Altruistic Kin Selection ......................... 50

4 Mating Dance ................................................. 53
  Basic Instinct ............................................... 53
    Scents of Love ............................................. 54
    Cupid's Chemicals .......................................... 55
  Mating Dance ................................................. 56
    Of Man and Ape ............................................. 57
    Sexual Matrimony and Polyamory ............................. 58
  And Less Love ................................................ 60
  Tug of War, In Utero ......................................... 64
  Back inlo the Past and Future ................................ 65

5 Quest for Perfection ......................................... 67
  Beauty Lies in the Eyes of the Beholder ...................... 67
    Ancient Definition of Perfection ........................... 68
    Search for the Perfect Face ................................ 69
    Search for Hour-Glass Figure ............................... 71
  The Myth of Beauty ........................................... 73
    The Cute Factor ............................................ 74
  No Choice for Baby ........................................... 77
    Selective Paternal Reproduction ............................ 79
      The Founding of Rome ..................................... 81
    Selective Maternal Reproduction ............................ 82
  Eugenics ..................................................... 83
    First Stage ................................................ 84
    Second Stage ............................................... 85
    Third Stage ................................................ 88
    Fourth Stage ............................................... 89

6 Invisible Hand in the Human Body Shop ........................ 91
  The Human Life Cycle ......................................... 91
    The Reproductive Cycle ..................................... 92
    Sex Hormones ............................................... 94
    Inside the Womb ............................................ 95
  Birth Defects ................................................ 98
  The Invisible Hand in Human Body Commerce ................... 102
    From Alchemy to Algeny .................................... 103
  In Vitro Fertilization ...................................... 105
    IVF the Aussie Style ...................................... 108
    The Business of In Vitro Fertilization .................... 110
    IVF Children .............................................. 111
  Donor Insemination .......................................... 112
    DI Half-Siblings .......................................... 114
  Hello Dolly, Good-Bye Dolly ................................. 115

7 Clonology ................................................... 119
  Parthenogenesis - Virgin Birth .............................. 119
  Cloning ..................................................... 120
    Clonology ................................................. 121
  Cloning Hollywood Style ..................................... 129
  The Celebrated Dolly, But Second to Computer Chips .......... 130
  Clones of Clones of a Clone ................................. 134
  Jerky Bulls and Yang Cows ................................... 136
  Second Chance - Clone of the Oldest Bull .................... 137
  Artificial Monkey Twins ..................................... 138
  Clone of a Clone - More Bulls ............................... 140
  Cloned Piglets .............................................. 141
  Reversing Aging ............................................. 142
  Other Notable Cloning Efforts ............................... 143
    Jurassic Amusement Park? .................................. 144
    More Calves and Piglets ................................... 146
    More Endangered Species Cloned ............................ 148
  Multi-Legged Bio-X .......................................... 149
    Multi-Legged Bio-Reactors ................................. 149
    Multi-Legged Bio-Facturers ................................ 152
      Nature Versus Nano ...................................... 154
    Multi-Legged Bio-Models ................................... 155
    Multi-Legged Bio-Factories ................................ 156

8 Petory and Biofactory ....................................... 159
  PerPETually Yours ........................................... 159
    K-9 Cloning ............................................... 160
    Snuppy .................................................... 162
    Dupli-Cat ................................................. 164
      Cc: Genetic Anomaly ..................................... 165
      Commercial Grade Pet Cloning ............................ 166
    Cloning Rabbitly .......................................... 168
    A Stubborn Clone .......................................... 169
    Cloned Equine Twin of Surrogate Mother .................... 171
  Ethically Yours ............................................. 172
    Odd-Inarily Yours ......................................... 173

9 Cloning Techniques .......................................... 179
  Twins -Twice the Fun ........................................ 179
    Nonidentical Twins - Siblings of the Same Age ............. 179
    Identical Twins - Natural Clones .......................... 180
      Mirror Image and Conjoined Twins ........................ 181
    Interest in Twins ......................................... 183
    Identical Twins are More Identical Than Clones ............ 184
  En Route to Commercialization ............................... 187
    Artificial Twinning Technique ............................. 188
    Nuclear Transfer Technique ................................ 191
      The Roslin Technique .................................... 192
      The Honolulu Technique .................................. 194
      The Chromatin Transfer Technique ........................ 195
  Twinning Roslin in Honolulu ................................. 197
    Honolulu Versus Dolly ..................................... 198
  First Male Clone ............................................ 199

10 Reproductive Human Cloning ................................. 203
   Super Clones? .............................................. 203
   Tinkering with Conception .................................. 204
   Natural Birth Versus Cloning ............................... 206
     Hardware and Software of Sexual Reproduction ............. 207
     Hardware and Software of Cloning ......................... 209
     Physiology of Human Cloning .............................. 210
   Key Human Cloning Mavericks ................................ 212
     Richard Seed ............................................. 213
     Claude Vorilhon and Brigitte Boisselier .................. 214
     Severino Antinori ........................................ 216
     Panayiotis Zavos ......................................... 217
     Avi Ben-Abraham .......................................... 218
   Human Embryo "Clones" ...................................... 220
     Clone Abortion ........................................... 221
     Why Hybrid? .............................................. 223
   The "Clone" Stork - Real or Rael? .......................... 224

11 The Alchemy of Stem Cells .................................. 227
   Organ Transplant ........................................... 227
   Growing Human Organs? ...................................... 229
   Stem Cell .................................................. 231
     Derivation of Stem Cells ................................. 232
     Banking Embryonic and Fetal Parts ........................ 234
     Lifeline - Cord Blood .................................... 235
     Multipotent Adult Stem Cells ............................. 238
   Stem Cells from Fat ........................................ 242
   Medical Uses of Stem Cells ................................. 246
     Stem Cell Gold Mines ..................................... 247
     Growing Breast from a Stem Cell .......................... 251
   Regenerative Medicine ...................................... 253
     Why Regenerative Medicine? ............................... 254
     Regenerative Medicine and Stem Cell Research ............. 256
   Regeneration, Stem Cells and Aging ......................... 258
   Master Cells and Master Genes .............................. 261

12 Stem Cell Entities ......................................... 265
   Stem Cell Nations .......................................... 265
     Sweden ................................................... 267
     United Kingdom ........................................... 268
     Australia ................................................ 269
     Singapore ................................................ 271
     Israel ................................................... 272
     Japan .................................................... 274
     India .................................................... 275
     China .................................................... 276
     Korea .................................................... 277
     United States ............................................ 279
       Case Study: Harvard Stem Cell Institute ................ 281
       Case Study: California Institute of Regenerative
         Medicine ............................................. 282
     East Versus West ......................................... 285
   A Shenanigans of Scandalous Proportion ..................... 287
     The Rise to International Stardom ........................ 288
     The Fall from Grace ...................................... 292
     The Repercussions ........................................ 301
     How Did It Happen? ....................................... 303
       The Way to the Top ..................................... 303
       The Way to Demise ...................................... 305
       The Bits and Pieces .................................... 305
       The Characters: Accomplices and Foes ................... 307
     Hwang Versus Raelians .................................... 311
     Synopsis of the Dogged Reports ........................... 313

13 Legal and Ethical Issues ................................... 317
   How? What? Why? ............................................ 317
     Therapeutic and Reproductive Cloning ..................... 320
     Secret Projects .......................................... 321
     Stigma of Cloning ........................................ 322
   Ten AD (After Dolly) ....................................... 323
     Cloning as an Assisted Reproductive Technology ........... 323
     All is Fine Unless You are the Clone ..................... 324
   Where Science Meets the Public ............................. 326
   Issues with Human Cloning .................................. 330
   Cloning as Reprotech ....................................... 333
   Ethical Issues with Cloning ................................ 335
     My Father is My Twin ..................................... 335
   Can a Clone Run for U.S. Presidency? ....................... 337
   The Genie is Out of the Bottle ............................. 340
     In Vitro Fertilization Debate ............................ 341
     Reproductive Cloning Dé Jà Vu ............................ 342
   Overcoming Legal and Ethical Impasse ....................... 343
     Private Funding .......................................... 345
     Model Organisms .......................................... 345
       Vertebrates ............................................ 346
       Invertebrates .......................................... 347
       Plants ................................................. 347
       Microorganisms ......................................... 347
   Circumventing Ethical Impasse .............................. 348
   Message in a Bottle from the Future ........................ 354
     To Clone or Not to Clone? ................................ 355
   Why? Why Not! .............................................. 356
     Clone the Law ............................................ 357

14 At the Crossroad ........................................... 359
   Relatively and Genetically Speaking ........................ 359
   Divinity Versus Greed ...................................... 362
     The Invisible Hand ....................................... 363
     Fictitious Commodities ................................... 365
     Tapping into Human Resources ............................. 366
     Mendel and Darwin ........................................ 367
   The Invisible Body ......................................... 369
   Sexual Reproduction Versus Cloning ......................... 373

Excellent References .......................................... 377

Food for Thoughts ............................................. 379

Index ......................................................... 387


 
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