Polya G. Biochemical targets of plant bioactive compounds (London, 2003). - ОГЛАВЛЕНИЕ / CONTENTS
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ОбложкаPolya G. Biochemical targets of plant bioactive compounds: a pharmacological reference guide to sites of action and biological effects - London: Taylor & Francis, 2003. - 847 p. - ISBN 0-415-30829-1
 

Оглавление / Contents
 
   List of tables .............................................. ix
   Preface ..................................................... xi

1  Plant defensive compounds and their molecular targets ........ 1
   1.1  Introduction ............................................ 1
   1.2  Organization and scope of the book ...................... 2
   1.3  Description of the tables ............................... 3
   1.4  Using the tables ........................................ 6
   1.5  The structural diversity of plant defensive compounds ... 6
   1.6  Plant alkaloids ......................................... 8
   1.7  Plant phenolics ........................................ 21
   1.8  Plant terpenes ......................................... 33
   1.9  Other plant compounds .................................. 44

2  Biochemistry - the chemistry of life ........................ 52
   2.1  Introduction - water-based life ........................ 52
   2.2  Protein structure ...................................... 53
   2.3  Enzymes and ligand-binding proteins .................... 58
   2.4  Metabolic strategies ................................... 66
   2.5  Inhibition of biochemical processes by plant
        defensive compounds .................................... 85

3  Neurotransmitter- and hormone-gated ion channels ............ 86
   3.1  Introduction - electrical signalling in excitable
        cells .................................................. 86
   3.2  lonotropic neurotransmitter receptors -
        neurotransmitter-gated ion channels .................... 88
   3.3  Structure and function of lonotropic receptors ......... 88

4  Ion pumps, ligand- and voltage-gated ion channels .......... 123
   4.1  Introduction .......................................... 123
   4.2  Ion pumps ............................................. 123
   4.3  Voltage-gated Na+ channels ............................ 125
   4.4  Ligand-regidated and voltage-gated K+ channels ........ 126
   4.5  Voltage-gated Ca2+ channels ........................... 126
   4.6  Ligand-gated Ca2+ channels ............................ 126
   4.7  Chloride transport and voltage-regulated chloride
        channels .............................................. 127

5  Plasma membrane G protein-coupled receptors ................ 157
   5.1  Introduction — signalling via heterotrimeric G
        proteins .............................................. 157
   5.2  G protein-coupled hormone and neurotransmitter
        receptors ............................................. 158
   5.3  Hormones and neurotransmitters acting via G
        protein-coupled receptors ............................. 159
   5.4  Activation of specific G protein-coupled receptors .... 160
   5.5  Leucocyte- and inflammation-related G protein-linked
        receptors ............................................. 162
   5.6  Other G protein-coupled receptors ..................... 164

6  Neurotransmitter transporters and converters ............... 231
   6.1  Introduction .......................................... 231
   6.2  Synthesis of neurotransmitters ........................ 232
   6.3  Release of neurotransmitters from synaptic vesicles ... 233
   6.4  Re-uptake of neurotransmitters into neurons and
        synaptic vesicles ..................................... 233
   6.5  Neurotransmitter degradation .......................... 233

7  Cyclic nucleotide-, Ca2+- and nitric oxide-based
   signalling ................................................. 253
   7.1  Introduction .......................................... 253
   7.2  Ca2+- and calmodulin-dependent enzymes ................ 254
   7.3  Adenylyl cyclase ...................................... 255
   7.4  Membrane-bound and soluble guanylyl cyclases .......... 255
   7.5  Nitric oxide synthesis ................................ 256
   7.6  Cyclic AMP- and cyclic GMP-dependent protein
        kinases ............................................... 257
   7.7  Protein kinase homologies and phosphoprotein
        phosphatases .......................................... 257
   7.8  Cyclic nucleotide phosphodiesterases .................. 258

8  Signal-regulated protein kinases ........................... 295
   8.1  Introduction .......................................... 295
   8.2  Cyclic AMP-dependent protein kinase ................... 296
   8.3  Cyclic GMP-dependent protein kinase ................... 297
   8.4  Protein kinase С ...................................... 298
   8.5  Ca2+-calmodulin-dependent protein kinases ............. 298
   8.6  AMP-dependent protein kinase .......................... 299
   8.7  Receptor tyrosine kinases ............................. 300
   8.8  Protein kinase В ...................................... 301
   8.9  Cytokine activation of the JAK / STAT pathway ......... 302
   8.10 Cell cycle control .................................... 303
   8.11 Receptor serine / threonine kinases ................... 303
   8.12 Other protein kinases ................................. 303
   8.13 Phosphoprotein phosphatases ........................... 304

9  Gene expression, cell division and apoptosis ............... 339
   9.1  Introduction .......................................... 339
   9.2  Regulation of gene expression in prokaryotes .......... 339
   9.3  Regulation of transcription in eukaryotes ............. 340
   9.4  RNA processing and translation ........................ 342
   9.5  Control of translation ................................ 342
   9.6  Protein processing andpost-translational
        modification .......................................... 343
   9.7  Protein targeting ..................................... 343
   9.8  Cell division and apoptosis ........................... 344
   9.9  HIV-1 infection and HIV-1 replication ................. 345
   9.10 Plant compounds interfering with gene expression ...... 345

10 Taste and smell perception, pheromones and
   semiochemicals ............................................. 396
   10.1  Introduction ......................................... 396
   10.2  Sweet taste receptors ................................ 397
   10.3  Bitter taste receptors ............................... 397
   10.4  Salty taste perception ............................... 398
   10.5  Sour task perception ................................. 398
   10.6  Umami (glutamate taste perception) ................... 398
   10.7  Odorant perception ................................... 398
   10.8  Animal pheromones and other animal bioactives
         produced by plants ................................... 399
   10.9  Other plant semiochemicals affecting animal
         behaviour ............................................ 399
   10.10 Odoriferous animal metabolites of ingested plant
         compounds ............................................ 399

11 Agonists and antagonists of cytosolic hormone receptors .... 452
   11.1  Introduction ......................................... 452
   11.2  Steroid hormones ..................................... 452
   11.3  Non-steroid cytosolic hormone receptor ligands ....... 453
   11.4  Plant bioactives affecting cytosolic
         receptor-mediated signalling ......................... 454

12 Polynucleotides, polysaccharides, phospholipids and
   membranes .................................................. 487
   12.1  Introduction ......................................... 487
   12.2  Polynucleotides ...................................... 488
   12.3  Polysaccharides and oligosaccharides ................. 489
   12.4  Phospholipids and membranes .......................... 490

13 Inhibitors of digestion and metabolism ..................... 517
   13.1  Introduction ......................................... 517
   13.2  Glycohydrolases ...................................... 517
   13.3  Proteases ............................................ 518
   13.4  Glycolysis and tricarboxylic acid cycle .............. 522
   13.5  Mitochondrial electron transport and oxidative
         phosphorylation ...................................... 522
   13.6  Gluconeogenesis ...................................... 523
   13.7  Solute translocation ................................. 524

14 Anti-inflammatory, antioxidant and antidiabetic plant
   compounds .................................................. 595
   14.1  Introduction ......................................... 595
   14.2  Adhesion and movement of inflammatory leucocytes ..... 596
   14.3  Chemokines ........................................... 596
   14.4  Phagocytosis ......................................... 597
   14.5  Kinins, cytokines, platelet activatingfactor and
         eicosanoids .......................................... 598
   14.6  Plant-derived anti-inflammatory compounds ............ 599
   14.7  Diabetes mellitus and plant antidiabetic compounds ... 599
   14.8  Summary .............................................. 601

Appendix: structures of key parent and representative
          compounds ........................................... 658

   Bibliography ............................................... 673
   Compound index ............................................. 678
   Plant genus index .......................................... 730
   Plant common names index ................................... 751
   Subject index .............................................. 779
   Abbreviations .............................................. 838


 
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