Comparative evalution of therapeutic radiopharmaceuticals (Vienna, 2007) - ОГЛАВЛЕНИЕ / CONTENTS
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ОбложкаComparative evalution of therapeutic radiopharmaceuticals. - Vienna: International Atomic Energy Agency, 2007. - 312 p. - (Technical Reports Series; N 458). - ISSN 0074-1914
 

Место хранения: 01 | ГПНТБ СО РАН | Новосибирск

Оглавление / Contents
 
PART I.	   OVERVIEW OF THE COORDINATED RESEARCH PROJECT

CHAPTER 1.   OBJECTIVES, RESULTS AND ACHIEVEMENTS OF
             THE COORDINATED RESEARCH PROJECT ................... 3

   1.1.  Introduction ........................................... 3
   1.2.  Objectives of the coordinated research project ......... 7
   1.3.  Overview of the work plan .............................. 7
   1.4.  Scientific achievements of the coordinated research
         project ............................................... 10
   1.5.  Conclusion and recommendations ........................ 12

CHAPTER 2.  PREPARATION AND QUALITY CONTROL OF
            177Lu-DOTATATE FOR TARGETED THERAPY ................ 17

   2.1.  Materials ............................................. 17
   2.2.  Preparation of 177Lu-DOTATATE .......................... 19
   2.3.  Quality control ....................................... 20
   2.4.  Storage of radiolabeled peptide ....................... 21
   2.5.  In vitro stability .................................... 21
   2.6.  Conclusion ............................................ 22

PART II. REPORTS BY PARTICIPANTS IN THE COORDINATED
         RESEARCH PROJECT

CHAPTER 3.  DEVELOPMENT OF SOMATOSTATIN BASED RADIO-
            PHARMACEUTICALS FOR RECEPTOR MEDIATED
            RADIONUCLIDE THERAPY ............................... 27
            E.B. Araújo, J.S. Caldeira Filho, L.T. Nagamati,
            E. Muramoto, M.T. Colturato, R. Couto, K. Okasaki,
            M.F. Suzuki, M.I.C.C. Guimaraes

   3.1.  Introduction .......................................... 27
   3.2.  Materials and methods ................................. 29
   3.3.  Results and discussion ................................ 35
   3.4.  Organ dosimetry ....................................... 45
   3.5.  Micronucleus assay .................................... 48

CHAPTER 4.  BIOLOGICAL EVALUATION OF RADIOTRACERS FOR
            RADIONUCLIDE THERAPY ............................... 53
            G.J. Pimentel, R. Ravelo, M. Miranda, J.
            Gavilondo, L. Pérez, M. Ayala, H. Bell, H.E.
            Garay, O. Reyes, I. Sanchez

   4.1.  Introduction .......................................... 54
   4.2.  Materials and methods ................................. 55
   4.3.  Results and discussion ................................ 61
   4.4.  Conclusion ............................................ 70

CHAPTER 5.  PRECLINICAL COMPARISON OF DOTATATE LABELLED WITH
            DIFFERENT RADIONUCLIDES ............................ 73
            M. Laznicek, A. Laznickova, F. Trejtnar, L.
            Melicharova, J. Cihlo, M. Petrik

   5.1.  Introduction .......................................... 74
   5.2.  Materials and methods ................................. 74
   5.3.  Results and discussion ................................ 79
   5.4.  Conclusion ............................................ 85

CHAPTER 6.  EVALUATION OF PEPTIDES LABELLED WITH BETA
            EMITTING RADIONUCLIDES FOR RECEPTOR TARGETED
            RADIOTHERAPY OF MALIGNANT TUMOURS .................. 87
            T. Maina, B. Nock, A. Nikolopoulou, C. Petrou,
            P. Cordopatis

   6.1.  Introduction .......................................... 88
   6.2.  Materials ............................................. 90
   6.3.  Methods ............................................... 91
   6.4.  Results ............................................... 95
   6.5.  Conclusion ........................................... 100

CHAPTER 7.  LABELLING AND BIOLOGICAL EVALUATION OF
            THERAPEUTIC RADIOPHARMACEUTICALS .................. 103
            G.A. Jánoki, A. Polyák, R. Király, L. Balogh,
            L. Kőrösi, D. Máthé

   7.1.  Introduction ......................................... 103
   7.2.  188Re labelled bone seeking and tumour specific
         agents for therapy ................................... 104
   7.3.  Radiolabelled receptor specific peptides for
         targeted use in diagnosis and therapy ................ 112

CHAPTER 8.  PREPARATION AND EVALUATION OF 177Lu-DOTATATE
            FOR POTENTIAL APPLICATION IN PEPTIDE RECEPTOR
            RADIONUCLIDE THERAPY .............................. 131
            S. Banerjee, S. Chakraborty, A. Korde, T. Das,
            A. Mukherjee, U. Pandey, H.D. Sarma, G. Samuel,
            P.S. Dhami, A.D. Ingle, M. Venkatesh

   8.1.  Introduction ......................................... 132
   8.2.  Materials ............................................ 133
   8.3.  Methods .............................................. 134
   8.4.  Results and discussion ............................... 143
   8.5.  177Lu labelling of other target specific ligands ...... 157
   8.6.  Conclusion ........................................... 161

CHAPTER 9.  OPTIMIZATION OF LABELLING CONDITIONS AND CELL
            BINDING ASSAY FOR 177Lu-DOTATATE ................... 163
            M. Chinol, Sun Ju Choi

   9.1.  Introduction ......................................... 163
   9.2.  Materials and methods ................................ 164
   9.3.  Results .............................................. 166
   9.4.  Conclusion ........................................... 168

CHAPTER 10. COMPARATIVE EVALUATION OF LABELLED BIOMOLECULES
            FOR TARGETED RADIOTHERAPY ......................... 169
            S.J. Choi, Y.D. Hong, S.M. Choi

   10.1. Introduction ......................................... 169
   10.2. Materials and methods ................................ 171
   10.3. Results .............................................. 173
   10.4. Conclusion ........................................... 177

CHAPTER 11. LABORATORY METHODS TO EVALUATE THERAPEUTIC
            RADIOPHARMACEUTICALS .............................. 181
            C. Arteaga de Murphy, G. Ferro-Flores, J.
            Rodriguez-Cortes, M. Pedraza-Lopez, M.T.
            Ramirez-Iglesias

   11.1. Introduction ......................................... 181
   11.2. Materials and methods ................................ 183
   11.3. Results .............................................. 188
   11.4. Discussion and conclusion ............................ 192

CHAPTER 12. LABORATORY EVALUATION OF THE BETA EMITTING
            RADIONUCLIDES 177Lu, 131I,153Sm AND 166Ho,
            AND RADIOPHARMACEUTICALS FOR RADIOTHERAPY ......... 197
            M.M. Ishfaq, H.J. Nizakat, K.M. Bashar,
            I. Haider

   12.1. Introduction ......................................... 198
   12.2. Materials ............................................ 199
   12.3. Methods .............................................. 199
   12.4. Results and discussion ............................... 204

CHAPTER 13. PRECLINICAL EVALUATION OF THERAPEUTIC
            RADIOPHARMACEUTICALS BASED ON 90Y AND 177Lu ........ 217
            D. Pawlak, A. Korsak, R. Mikolajczak, B. Janota,
            U. Karczmarczyk, E. Jakubowska

   13.1. Introduction ......................................... 217
   13.2. Methods .............................................. 217
   13.3. Results .............................................. 221
   13.4. Conclusion ........................................... 231

CHAPTER 14. LABELLING OF DOTATATE WITH 177Lu AND 131I FOR
            DIAGNOSIS AND TARGETED THERAPY: IN VITRO AND
            IN VIVO COMPARATIVE EVALUATION .................... 233
            V. Lungu, D. Niculae, D. Chiper, R. Mihai, L.
            Danaila, S. Baiculescu

   14.1. Introduction ......................................... 234
   14.2. Materials ............................................ 234
   14.3. Methods .............................................. 235
   14.4. Results .............................................. 240
   14.5. Conclusion ........................................... 254

CHAPTER 15. PRECLINICAL DEVELOPMENT OF THERAPEUTIC
            RADIOPHARMACEUTICALS .............................. 257
            S.J. Mather

   15.1. Introduction ......................................... 257
   15.2. Radiopharmaceutical design ........................... 258
   15.3. Synthesis or purchase of precursor ................... 259
   15.4. Radiolabelling development ........................... 260
   15.5. Analyses of radiochemical purity ..................... 260
   15.6. Stability assessment ................................. 261
   15.7. Receptor binding ..................................... 262
   15.8. Cellular processing and metabolism ................... 263
   15.9. In vivo biodistribution and targeting ................ 264
   15.10.In vitro and in vivo measures of efficacy ............ 265

CHAPTER 16. LABORATORY EVALUATION OF THERAPEUTIC
            BIOMOLECULES LABELLED WITH RADIOIODINE
            AND LUTETIUM ...................................... 269
            H.S. Balter, P. Oliver, A. Robles, N. Berois,
            P. Cabral, A. Nappa, A. López, V. Trindade, G.
            Rodríguez, S. Lanzzeri, S. Verdera

   16.1. Introduction ......................................... 270
   16.2. Materials ............................................ 271
   16.3. Methods .............................................. 271
   16.4. Results .............................................. 278
   16.5. Conclusion ........................................... 290

APPENDIX I:  PROTOCOLS DEVELOPED AS PART OF THE COORDINATED
             RESEARCH PROJECT ................................. 295
APPENDIX II:  PAPERS PUBLISHED BY THE PARTICIPANTS RELATED
              TO THE COORDINATED RESEARCH PROJECT ............. 306

LIST OF PARTICIPANTS .......................................... 311


 
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