Preface ......................................................... v
Acronyms and Abbreviations ..................................... xi
Part 1. Structure and Biological Function of Glycoconjugates .... 1
Chapter 1 Glycoproteins: Chemical Features and Biological
Roles ................................................ 3
Yanhong Li, Xixuan Li and Xi Chen
Chapter 2 Gangliosphingolipids: Structure and Biological
Roles ............................................... 35
Sophie Groux-Degroote, Yann Guérardel and Philippe
Delannoy
Chapter 3 Bacterial Lipopolysaccharides: An Overview of
Their Structure, Biosynthesis and Immunological
Activity ............................................ 57
Flaviana Di Lorenzo, Alba Silipo, Rosa Lanzetta,
Michelangelo Parrilli and Antonio Molinaro
Part 2. Towards Glycomics: Methodologies and Techniques for
the Determination of Structure and Activity Relationship ....... 91
Chapter 4 Mass Spectrometry: Updates in the Elucidation
of Structure of Oligosaccharides .................... 93
Maria Michela Corsaro
Chapter 5 Advanced NMR Techniques: Defining Carbohydrate
Structures and Ligand-Receptor Interactions ........ 121
M. Álvaro Berbis, Ángeles Canales, Javier Sastre-
Martinez, Luca Unione, M.C. Fernández-Alonso,
Pilar Blasco, F. Javier Cañada and Jesús
Jiménez-Barbero
Chapter 6 Glycoarrays: An Invaluable Tool for Glycomics ...... 147
Niels-Christian Reichardt, Sonia Serna and Juan
Echevarria
Chapter 7 Informatics and Analytical Tools for Glycan
Analysis and the Development of Biotherapeutics .... 173
Catherine A. Hayes, Giorgio Carta, Niclas
G. Karlsson. Fergal Duffy and Pauline M. Rudd
Part 3. Synthetic Challenges: Towards Drug Development ........ 193
Chapter 8 Classical Tools for Oligosaccharide Synthesis ...... 195
Daniel B. Werz
Chapter 9 When Enzymes Do It Better: Enzymatic Glycosylation
Methods ............................................ 215
Antoni Planas, Magda Faijes and Victoria Codera
Chapter 10 Automated Chemical Synthesis of Oligosaccharides
and Glycoconjugates ................................ 247
Salvatore G. Pistorio, Keith J. Sline and Alexei
V. Demchenko
Part 4. Carbohydrate-Based Compounds for Medicinal Chemistry
Applications .................................................. 277
Chapter 11 Iminosugars: The Potential of Carbohydrate
Analogs ............................................ 279
Naoki Asano
Chapter 12 Vaccines against Bacterial Pathogens: A General
Overview ........................................... 303
Darielys Santana Medero, Dagmar Garcia Rivera,
Yury Valdes Balbin and Vicente Verez Bencomo
Chapter 13 Carbohydrate-Based Antibacterial Vaccines:
Current Progress and Future Outlook ................ 321
Sachin S. Shivatare and Chung-Yi Wu
Chapter 14 Synthetic Vaccines against Cancers ................. 357
Michele Flore, Baptiste Thomas, Gour Chand
Daskhan and Olivier Renaudet
Chapter 15 DC-SIGN as a Target for Drug Development Based on
Carbohydrates ...................................... 379
Sara Sattin, Franck Fieschi and Anna Bernardi
Chapter 16 Carbohydrates, Biomaterials, and Tissue
Engineering Applications ........................... 395
Laura Russo, Antonella Sgambato, Davide Bini,
Ilaria Calloni, Davide Origgi, Fatma Cetin Telli
and Laura Cipolla
Chapter 17 Carbohydrate Multivalent Systems: Synthesis and
Therapeutic Opportunities .......................... 419
Jose J. Reina and Javier Rojo
Chapter 18 Anti tubercular Drugs Based on Carbohydrate
Derivatives ........................................ 441
Vishwanath Gaitonde and Steven J. Sucheck
Part 5. Conclusion ............................................ 479
Chapter 19 Carbohydrate-Based Drugs on the Market:
Overview and Future Directions ..................... 481
Matteo Gentili and Oscar Francesconi
Index ......................................................... 501
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