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ОбложкаCyclic-nucleotide phosphodiesterases in the central nervous system: from biology to drug discovery. - Hoboken: Wiley, 2014. - xi, 386 p.: ill. + 4 l. ill. - (Wiley series in drug discovery and development). - Bibliogr. at the end of the chapters. - Ind.: p.375-386. - ISBN 978-0-470-56668-8
Шифр: (И/Е0-С98) 02
 

Место хранения: 02 | Отделение ГПНТБ СО РАН | Новосибирск

Оглавление / Contents
 
PREFACE ....................................................... vii
CONTRIBUTORS ................................................... ix

1  PHOSPHODIESTERASES AND CYCLIC NUCLEOTIDE SIGNALING IN THE 
   CNS .......................................................... 1
   Marco Conti and Wito Richter
2  PUTTING TOGETHER THE PIECES OF PHOSPHODIESTERASE 
   DISTRIBUTION PATTERNS IN THE BRAIN: A JIGSAW PUZZLE OF 
   CYCLIC NUCLEOTIDE REGULATION ................................ 47
   Michy P. Kelly
3  COMPARTMENTALIZATION AND REGULATION OF CYCLIC NUCLEOTIDE
   SIGNALING IN THE CNS ........................................ 59
   Manuela Zaccolo and Alessandra Stangherlin
4  PHARMACOLOGICAL MANIPULATION OF CYCLIC NUCLEOTIDE 
   PHOSPHODIESTERASE SIGNALING FOR THE TREATMENT OF 
   NEUROLOGICAL AND PSYCHIATRIC DISORDERS IN THE BRAIN ......... 77
   Frank S. Menniti, Niels Plath, Niels Svenstrup, and 
   Christopher J. Schmidt
5  RECENT RESULTS IN PHOSPHODIESTERASE INHIBITOR DEVELOPMENT
   AND CNS APPLICATIONS ....................................... 115
   David P. Rotella
6  CRYSTAL STRUCTURES OF PHOSPHODIESTERASES AND IMPLICATION
   ON DISCOVERY OF INHIBITORS ................................. 145
   Hengming Ke, Huanchen Wang, Mengchun Ye, and Yingchun
   Huang
7  INHIBITION OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASES TO
   REGULATE MEMORY ............................................ 171
   Han-Ting Zhang, Ying Xu, and James O'Donnell
8  EMERGING ROLE FOR PDE4 IN NEUROPSYCHIATRIC DISORDERS: 
   TRANSLATING ADVANCES FROM GENETIC STUDIES INTO RELEVANT
   THERAPEUTIC STRATEGIES ..................................... 211
   Sandra P. Zoubovsky, Nicholas J. Brandon, and Akira Sawa
9  BEYOND ERECTILE DYSFUNCTION: UNDERSTANDING PDE5 ACTIVITY 
   IN THE CENTRAL NERVOUS SYSTEM .............................. 223
   Eva P.P. Bollen, Kris Rutten, Olga A.H. Reneerkens,
   Harry M.W. Steinbusch, and Jos Prickaerts
10 MOLECULAR AND CELLULAR UNDERSTANDING OF PDE10A: A DUAL-
   SUBSTRATE PHOSPHODIESTERASE WITH THERAPEUTIC POTENTIAL
   TO MODULATE BASAL GANGLIA FUNCTION ......................... 247
   Erik I. Charych and Nicholas J. Brandon
11 ROLE OF CYCLIC NUCLEOTIDE SIGNALING AND PHOSPHODIESTERASE 
   ACTIVATION IN THE MODULATION OF ELECTROPHYSIOLOGICAL
   ACTIVITY OF CENTRAL NEURONS ................................ 269
   Sarah Threlfell and Anthony R. West
12 THE ROLE OF PHOSPHODIESTERASES IN DOPAMINE SYSTEMS 
   GOVERNING MOTIVATED BEHAVIOR ............................... 303
   Gretchen L. Snyder, Joseph P. Hendrick, and Akinori Nishi
13 INHIBITION OF PHOSPHODIESTERASES AS A STRATEGY FOR 
   TREATMENT OF SPINAL CORD INJURY ............................ 353
   Elena Nikulina and Marie T. Filbin

INDEX ......................................................... 375

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