Engineering polymer systems for improved drug delivery (Hoboken, 2014). - ОГЛАВЛЕНИЕ / CONTENTS

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ОбложкаEngineering polymer systems for improved drug delivery / ed. by R.A.Bader, D.A.Putnam. - Hoboken: Wiley, 2014. - xvi, 474 p.: ill., tab. - Bibliogr. at the end of the chapters. - Ind.: p.453-474. - ISBN 978-1-118-09847-9
 

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Оглавление / Contents
 
FOREWORD ....................................................... xi
PREFACE ...................................................... xiii
CONTRIBUTORS ................................................... xv
   
PART I  INTRODUCTION ............................................ 1

1  FUNDAMENTALS OF DRUG DELIVERY ................................ 3
   Rebecca A. Bader
   1.1  Introduction: History and Future of Drug Delivery ....... 3
   1.2  Terminology ............................................. 5
   1.3  Basic Pharmacokinetics .................................. 8
   1.4  Basic Pharmacodynamics ................................. 12
   1.5  Mass Transfer .......................................... 13
   1.6  Key Points ............................................. 23
   1.7  Homework Problems ...................................... 23
   
2  CHALLENGES OF DRUG DELIVERY ................................. 29
   Patricia R. Wardwell and Rebecca A. Bader
   2.1  Introduction ........................................... 29
   2.2  History and Challenges of Drug Delivery ................ 30
   2.3  Physical Barriers ...................................... 31
   2.4  Metabolic and Chemical Concerns ........................ 39
   2.5  Physical Properties of Therapeutics .................... 42
   2.6  Polymer Carriers as a Solution to Challenges ........... 45
   2.7  Key Points ............................................. 50
   2.8  Homework Problems ...................................... 50
   
PART II INJECTABLE POLYMERIC DRUG DELIVERY SYSTEMS ............. 55

3  POLYMER-DRUG CONJUGATES ..................................... 57
   Cristina Fante and Francesca Greco
   3.1  Introduction ........................................... 57
   3.2  Historical Perspective ................................. 58
   3.3  Polymer-Drug Conjugates: Biological Rationale .......... 59
   3.4  Structural Features of Polymer-Drug Conjugates ......... 62
   3.5  Making a Polymer-Drug Conjugate ........................ 68
   3.6  Current Challenges and Future Perspectives ............. 71
   3.7  Key Points ............................................. 75
   3.8  Worked Example ......................................... 76
   3.9  Homework Problems ...................................... 76
4  POLYMERIC MICROPARTICLES .................................... 85
   Noelle K. Comolli and Colleen E. Clark
   4.1  Introduction ........................................... 85
   4.2  The Rationale for Microparticles ....................... 86
   4.3  Defining the Design Criteria ........................... 87
   4.4  Polymer Selection ...................................... 89
   4.5  Microparticle Synthesis ................................ 91
   4.6  Microparticle Characterization Methods ................. 96
   4.7  Drag Release from Microparticles ...................... 100
   4.8  Microparticle Design Examples ......................... 108
   4.9  Key Points ............................................ 110
   4.10 Worked Example ........................................ 110
   4.11 Homework Problems ..................................... 111
5  POLYMERIC NANOPARTICLES .................................... 117
   Andrew L. Vasilakes, Thomas D. Dziubla, and Paritosh 
   P. Wattamwar
   5.1  Introduction .......................................... 117
   5.2  PNP Design ............................................ 124
   5.3  PNP Formulation Methods and Targeting ................. 128
   5.4  Nanoparticle Targeting Overview ....................... 133
   5.5  PNP Characterization .................................. 139
   5.6  Major Clinical Achievements ........................... 147
   5.7  Key Points ............................................ 148
   5.8  Worked Example ........................................ 149
   5.9  Homework Problems ..................................... 150
6  BLOCK COPOLYMER MICELLES AND VESICLES FOR DRUG DELIVERY .... 163
   James D. Robertson, Nisa Patikarnmonthon, Adrian S. 
   Joseph, and Giuseppe Battaglia
   6.1  Introduction .......................................... 163
   6.2  Drug Encapsulation and Release ........................ 165
   6.3  Bioavailability and Biodistribution ................... 166
   6.4  Stimuli Responsiveness ................................ 170
   6.5  The Immune System ..................................... 174
   6.6  Gene Therapy .......................................... 177
   6.7  Cancer Therapy ........................................ 180
   6.8  Conclusions ........................................... 182
   6.9  Key Points ............................................ 182
   6.10 Homework Problems ..................................... 183
   
PART III IMPLANTABLE POLYMERIC DRUG DELIVERY SYSTEMS .......... 189
7  IMPLANTABLE DRUG DELIVERY SYSTEMS .......................... 191
   Luis Solorio, Angela Carlson, Haoyan Zhou, and Agata 
   A. Exner
   7.1  Introduction .......................................... 191
   7.2  Nondegradable Polymeric Implants ...................... 193
   7.3  Biodegradable Polymeric Implants ...................... 198
   7.4  Conclusions and Future Perspectives ................... 215
   7.5  Key Points ............................................ 216
   7.6  Homework Problems ..................................... 216
8  POLYMERIC DRUG DELIVERY SYSTEMS IN TISSUE ENGINEERING ...... 227
   Matthew Skiles and James Blanchette
   8.1  Introduction .......................................... 227
   8.2  Wound Healing as a Prototype for Adult Tissue 
        Generation ............................................ 228
   8.3  Bioactive Factors in Tissue Engineering and 
        Regenerative Medicine ................................. 232
   8.4  Delivery of Growth Factors in Tissue Engineering 
        and Regenerative Medicine ............................. 248
   8.5  Key Points ............................................ 268
   8.6  Worked Example ........................................ 269
   8.7  Homework Problems ..................................... 270

PART IV ORAL POLYMERIC DRUG DELIVERY SYSTEMS .................. 283

9  ORAL CONTROLLED-RELEASE POLYIVIERIC DRUG DELIVERY SYSTEMS .. 285
   James W. McGinity, James C. DiNunzio, and Justin M. Keen
   9.1  Introduction .......................................... 285
   9.2  Release Mechanisms of Oral Polymeric Dosage Forms ..... 288
   9.3  Oral Polymeric Release Modifiers ...................... 295
   9.4  Manufacturing Technologies and Industrial 
        Applications of Controlled Release .................... 297
   9.5  Worked Example ........................................ 311
   9.6  Key Points ............................................ 314
   9.7  Homework Problems ..................................... 314
10 MUCOADHESIVE DRUG DELIVERY SYSTEMS ......................... 319
   Srinath Muppalaneni, David Mastropietro, and Hossein 
   Omidian
   10.1  Introduction ......................................... 319
   10.2  Factors Affecting Mucoadhesion ....................... 320
   10.3  Polymer-Mucus Interactions ........................... 320
   10.4  Mucoadhesion Mechanisms .............................. 322
   10.5  Mucoadhesive Polymers ................................ 324
   10.6  Novel Mucoadhesive Materials ......................... 327
   10.7  Mucoadhesion Testing ................................. 330
   10.8  Drug Release Studies ................................. 332
   10.9  Mucoadhesive Dosage Forms ............................ 332
   10.10 Conclusion ........................................... 334
   10.11 Key Points ........................................... 334
   10.12 Homework Questions ................................... 337
11 ENHANCED ORAL DRUG DELIVERY THROUGH METABOLIC PATHWAYS ..... 343
   Gregory Russell-Jones
   11.1 Introduction .......................................... 343
   11.2 Uptake of Nutrients from the Intestine ................ 344
   11.3 Nutrient Transport in the Intestine ................... 349
   11.4 Use of Nutrient Transporters for Drug Delivery ........ 352
   11.5 Case Study: The Use of the Vitamin B2 Uptake System 
        for Drug Delivery ..................................... 352
   11.6 Key Points ............................................ 365
   11.7 Worked Example ........................................ 365
   11.8 Homework Problems ..................................... 366
   
PART V ADVANCED POLYMERIC DRUG DELIVERY ....................... 375
12 STIMULI-RESPONSIVE POLYMER DELIVERY SYSTEMS ................ 377
   Amy Van Hove, Zhanwu Cui, and Danielle S.W. Benoit
   12.1 Introduction .......................................... 377
   12.2 Temperature-Responsive Polymers for Drug Delivery ..... 378
   12.3 pH-Responsive Polymers for Drug Delivery .............. 387
   12.4 Reduction/Oxidation (Redox)-Responsive Polymers ....... 397
   12.5 Enzymatically Responsive Drug Delivery ................ 403
   12.6 Key Points ............................................ 415
   12.7 Homework Questions .................................... 416
13 AFFINITY-BASED DRUG DELIVERY ............................... 429
   Andrew S. Fu and Horst A. von Recum
   13.1 Introduction .......................................... 429
   13.2 Association Constant .................................. 430
   13.3 Worked Example ........................................ 432
   13.4 Affinity-Based Drug Delivery Systems .................. 437
   13.5 Mathematical Modeling of Affinity-Based Systems ....... 444
   13.6 Challenges and Future Directions ...................... 448
   13.7 Key Points ............................................ 448
   13.8 Homework Problems ..................................... 449

INDEX ......................................................... 453


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