Армейская авиация НОАК: пер. с кит. (Пекин, 2013). - ОГЛАВЛЕНИЕ / CONTENTS

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ОбложкаCellular therapy of cancer: development of gene therapy based approaches / ed.: R.E.Hawkins. - Singapore [et al.]: World scientific, 2014. - vii, 201 p.: ill., tab. - Bibliogr. at the end of the chapters. - ISBN 978-981-4295-13-0
 

Место хранения: 02 | Отделение ГПНТБ СО РАН | Новосибирск

Оглавление / Contents
 
Chapter 1. Challenges of T-Cell Therapy ......................... 1
Naomi Taylor, Anna Mondino and Balbino Alarcon
1.1  T-Cell Homeostasis ......................................... 1
1.2  Lymphopenia and Immune Responsiveness to Self-Antigens ..... 2
1.3  CD4 and CD8 T-Cell Differentiation States .................. 3
1.4  T-Cell Persistence and Trafficking to Tumor ................ 6
1.5  Choice of Target Antigen ................................... 9
References ...................................................... 9

Chapter 2. Gene Transfer into T Cells .......................... 19
David Gilham and Hinrich Abken
2.1  Introduction .............................................. 19
2.2  γ-Retroviral Vectors to Generate Gene-Modified T Cells .... 21
2.3  The Potential Drawbacks of γ-Retroviral Vectors, for
     T-Cell Gene Therapy ....................................... 22
2.4  Improving All Aspects of γ-Retroviral Gene Transfer to
     Preserve or Enhance Antigen-Specific T-Cell Function
     In Vivo ................................................... 26
2.5  Lentiviral Vectors to Transduce Minimally Stimulated and
     Quiescent Primary Human T Cells ........................... 29
2.6  Other Viral Vectors Used to Transduce Primary Human
     T Cells ................................................... 31
2.7  Non-Viral Gene Transfer Into Primary Human T Cells:
     Plasmid-Based Systems ..................................... 33
2.8  Non-Viral Gene Transfer Into Primary Human T Cells:
     Transposon Technology ..................................... 34
2.9  Non-Viral Gene Transfer Into Primary Human T Cells: RNA
     Vectors ................................................... 35
2.10 Mouse Models of Gene-Modified T-Cell Therapy .............. 38
2.11 Summary ................................................... 38
References ..................................................... 39

Chapter 3. TCR-Engineered T cells .............................. 49
Reno Debets and Ton Schumacher
3.1  Introduction .............................................. 49
3.2  Generation of TCR T Cells That are Not or Minimally
     Self-Reactive ............................................. 52
3.3  Generation of TCR T Cells with Enhanced Functional
     Avidity ................................................... 60
3.4  Next Steps in TCR Gene Therapy ............................ 67
References ..................................................... 70

Chapter 4. T-Bodies: Antibody-Based Engineered T-Cell
Receptors ...................................................... 83
John Bridgeman, Andreas A. Hombach, David Gilham, Zelig
Eshhar and Hinrich Abken
4.1  Overview .................................................. 83
4.2  A Long Way to the One-Chain Format: A Brief History of
     T-Bodies .................................................. 84
4.3  From Structure to Function ................................ 85
4.4  Clinical Studies ......................................... 103
4.5  Perspectives ............................................. 111
4.6  Summary .................................................. 116
References .................................................... 117

Chapter 5   T-Cell Engineering and Expansion - GMP Issues ..... 131
Cor Lamers and Ryan Guest
5.1  Introduction ............................................. 131
5.2  Clinical Vectors ......................................... 133
5.3  Ex Vivo Generation of Gene-Modified T Cells .............. 144
5.4  Data Management and Regulatory Aspects ................... 163
5.5  Future Developments ...................................... 165
References .................................................... 167

Chapter 6. Clinical Trial Design .............................. 179
Robert Hawkins, John Haanen and Fiona Thistlethwaite
6.1  Introduction ............................................. 179
6.2  Background ............................................... 179
6.3  TIL Therapy .............................................. 181
6.4  Engineered T Cells - Clinical Trials ..................... 186
6.5  Toxicities and Safety of ACT ............................. 190
6.6  Future Strategies ........................................ 193
6.7  Conclusions .............................................. 196
References .................................................... 196


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