Wnt signaling in development and disease: molecular mechanisms and biological functions (Hoboken, 2014). - ОГЛАВЛЕНИЕ / CONTENTS

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ОбложкаWnt signaling in development and disease: molecular mechanisms and biological functions / ed. by S.Hoppler, R.T.Moon. - Hoboken: John Wiley & Sons, 2014. - ix, 459 p., [24] p. col. ill.: ill. - Incl. bibl. ref. - Ind.: p.445-459. - ISBN 978-1-1184-4416-0
 

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Оглавление / Contents
 
Contributors .................................................. vii
Preface ........................................................ xi

Part 1  Molecular Signaling Mechanisms: From Pathways to 
Networks ........................................................ 1
1  Wnt Signal Production, Secretion, and Diffusion .............. 3
   Madeion M. Maurice and Hendrik С. Korswagen
2  Wnt Signaling at the Membrane ............................... 15
   Gary Davidson and Christof Niehrs
3  Wnt Signal Transduction in the Cytoplasm: an Introduction 
   to the Destruction Complex .................................. 33
   Tony W. Chen, Heather A. Wallace, Yashi Ahmed, and Ethan 
   Lee
4  An Overview of Gene Regulation by Wnt/ß-Catenin Signaling ... 51
   Chen U. Zhang and Ken M. Cadigan
5  Finding a Needle in a Genomic Haystack: Genome-Wide 
   Approaches to Identify Wnt/TCF Transcriptional Targets ...... 73
   Chandan Bhambhani and Ken M. Cadigan
6  Introduction to β-Catenin-Independent Wnt Signaling
   Pathways .................................................... 89
   Susanne Kühl and Michael Kühl
7  Molecular Mechanisms of Wnt Pathway Specificity ............ 101
   Alexandra Schambony, Guido J.R. Zaman, and Folkert Verkaar
8  Modulation of Wnt Signaling by Endocytosis of Receptor 
   Complexes .................................................. 113
   Akira Kikuchi, Shinji Matsumoto, Katsumi Fumoto, and
   Akira Sato
9  New Insights from Proteomic Analysis of Wnt Signaling ...... 125
   Matthew P. Walker, Dennis Goldfarb, and Michael B. Major
10 New Insights about Wnt/Я-Catenin Pathway Mechanisms from
   Global siRNA Screens ....................................... 137
   Tenzin Gocha and Ramanuj DasGupta
11 Mathematical Models of Wnt Signaling Pathways .............. 153
   Michael Kühl, Barbara Kracher, Alexander Groß, and Hans 
   A. Kestler
12 The Wnt's Tale: On the Evolution of a Signaling Pathway .... 161
   Jenifer C. Croce and Thomas W. Holstein

Part 2  Selected Key Molecules in Wnt Signaling ............... 177
13 Secreted Wnt Inhibitors or Modulators ...................... 179
   Paola Bovolenta, Anne-Kathrin Gorny, Pilar Esteve, and
   Herbert Steinbeisser
14 Frizzleds as G Protein-Coupled Receptors ................... 195
   Gunnar Schulte
15 Dishevelled at the Crossroads of Pathways .................. 207
   Vítězslav Bryja and Ondřej Bernatík
16 ß-Catenin: a Key Player in Both Cell Adhesion and Wnt
   Signaling .................................................. 217
   Jonathan Pettitt
17 Evolutionary Diversification of Vertebrate TCF/LEF 
   Structure, Function, and Regulation ........................ 225
   Stefan Hoppler and Marian L. Waterman
18 Insights from Structural Analysis of Protein-Protein 
   Interactions by Wnt Pathway Components and Functional 
   Multiprotein Complex Formation ............................. 239
   Zhihong Cheng and Wenqing Xu

Part 3  Wnt Signaling in Embryonic Development and Adult 
Tissue Homeostasis ............................................ 251
19 Wnt Signaling in Early Vertebrate Development: From
   Fertilization to Gastrulation .............................. 253
   Eliza Zylkiewicz, Sergei Y. Sokol, and Stefan Hoppler
20 Wnt/ß-Catenin Signaling in Embryonic Stem Cells: Insights 
   into Early Mammalian Development ........................... 267
   Kathryn C. Davidson
21 Wnt Signaling in Neural Development ........................ 279
   Richard I. Dorsky
22 Wnt Signaling in Heart Organogenesis ....................... 293
   Stefan Hoppler, Silvia Mazzotta, and Michael Kühl
23 Wnt Signaling in Kidney Organogenesis ...................... 303
   Kimmo Halt and Seppo Vainio
24 Wnt Signaling Regulation of Tissue Architecture (EMT and 
   MET) and Morphogenesis: Consequences for Colorectal and
   Liver Cancer ............................................... 315
   Theodora Fifis, Bang M. Tran, Renate H.M. Schwab,
   Timothy M. Johanson, Nadia Warner, Nick Barker, and 
   Elizabeth Vincan
25 Wnt Signaling in Adult Stem Cells: Tissue Homeostasis
   and Regeneration ........................................... 329
   Frank J.T. Staal and Riccardo Fodde
26 Restoring Tissue Homeostasis: Wnt Signaling in Tissue 
   Regeneration After Acute Injury ............................ 339
   Günes Özhan and Gilbert Weidinger

Part 4 Wnt Signaling in Chronic Disease ....................... 357
27 Wnt Signaling and Colorectal Cancer ........................ 359
   Kevin Myant and Owen J. Sansom
28 Wnt Signaling in Melanoma .................................. 369
   Jamie N. Anastas and Andy J. Chien
29 Wnt Signaling in Mood and Psychotic Disorders .............. 379
   Stephen J. Haggarty, Karun Singh, Roy H. Perlis, and
   Rakesh Karmacharya
30 Neuropsychiatric Disease-Associated Genetic Variation in
   the Wnt Pathway ............................................ 393
   Stephen J. Haggarty, Karun Singh, Roy H. Perlis, and 
   Rakesh Karmacharya
31 Wnt Signaling in Dementia .................................. 411
   Stephen J. Haggarty
32 Therapeutic Targeting of the Wnt Signaling Network ......... 421
   Felicity Rudge and Trevor Dale

Index ......................................................... 445


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