Biomedical imaging: applications and advances (Cambridge; Waltham, 2014). - ОГЛАВЛЕНИЕ / CONTENTS

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ОбложкаBiomedical imaging: applications and advances / ed. by P.Morris. – Cambridge; Waltham: Elsevier/ WP, 2014. - xxv,318 p.: ill. - (Woodhead publishing series in biomaterials; N 63). - Bibliogr. at the end of the chapters. - Ind.: p.307-318. - ISBN 978-0-85709-127-7
 

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Оглавление / Contents
 
   Contributor contact details ................................. ix
   Woodhead Publishing Series in Biomaterials ................ xiii
   Foreword ................................................... xix
   Preface .................................................. xxiii

Part I  Imaging technologies .................................... 1

1  Biomedical Positron Emission Tomography (PET) imaging ........ 3
   S. Chua, The Royal Marsden Hospital, UK and
   A. Groves, UCL Institute of Nuclear Medicine, UK
   1.1  Introduction ............................................ 3
   1.2  The role of PET in oncology ............................. 7
   1.3  Individual oncological PET tracers and their
        applications ........................................... 13
   1.4  The role of PET in neurology ........................... 22
   1.5  The role of PET in cardiology .......................... 25
   1.6  The role of PET in drug development .................... 27
   1.7  Conclusion and future trends ........................... 29
   1.8  References ............................................. 32

2  Atomic Force Microscopy (AFM) in biomedical research ........ 41
   S. Rao and K.D. Costa, Icahn School of Medicine at Mount
   Sinai, USA
   2.1  Introduction ........................................... 41
   2.2  Key concepts of atomic force microscopy (AFM) .......... 42
   2.3  AFM imaging methodologies .............................. 46
   2.4  AFM nano-indentation ................................... 52
   2.5  Specialized techniques ................................. 57
   2.6  Conclusion and future trends ........................... 61
   2.7  Bibliography ........................................... 62

3  Next generation techniques for biomedical imaging ........... 65
   J.L. Richens and R. O'Shea, University of Nottingham, UK
   3.1  Introduction ........................................... 65
   3.2  An overview of imaging sciences ........................ 66
   3.3  New developments to improve diagnosis and biological
        analysis ............................................... 69
   3.4  Imaging techniques: imaging Omics and array
        imaging ................................................ 70
   3.5  Plasmonics ............................................. 73
   3.6  iBIOS Omics imaging: instrument assembly ............... 74
   3.7  Label-free measurements: problems of non-specific
        binding and the analyte dynamic range .................. 75
   3.8  Data correction and analysis ........................... 80
   3.9  Biomarker panel analysis ............................... 83
   3.10 Future trends in Omics imaging ......................... 85
   3.11 Conclusion ............................................. 87
   3.12 Sources of further information and advice .............. 88
   3.13 Acknowledgement ........................................ 88
   3.14 References ............................................. 89
   
Part II Application-specific biomedical imaging techniques ..... 93
   
4  Brain imaging: assessing therapy responses using
   quantitative imaging biomarkers ............................. 95
   M. Hwang, M. Oborski, C. Laymon, F. Imani and J. Mountz, 
   University of Pittsburgh, USA
   4.1  Introduction ........................................... 95
   4.2  Epidemiology and classification of brain tumors ........ 95
   4.3  Treatment .............................................. 96
   4.4  The role of neuroimaging: computed tomography (CT)
        and magnetic resonance (MR) ............................ 96
   4.5  The role of neuroimaging: PET and tracers ............. 100
   4.6  Conclusion ............................................ 104
   4.7  Acknowledgements ...................................... 104
   4.8  References ............................................ 104

5  Neural brain activation imaging ............................ 112
   R.M. Sanchez Panchuelo, M.C. Stephenson, S.T. Francis and
   P.G. Morris, University of Nottingham, UK
   5.1  Introduction .......................................... 112
   5.2  Functional magnetic resonance imaging (fMRI) .......... 112
   5.3  Multimodal imaging .................................... 129
   5.4  13C magnetic resonance spectroscopy (MRS) ............. 133
   5.5  Sources of further information and advice ............. 144
   5.6  References ............................................ 144
   
6  Ophthalmic imaging of ocular circulation for detecting
   disease .................................................... 163
   A. Harris, B. Siesky, S. Primus, M. Zore and L. Abrams
   Tobe, Indiana University School of Medicine, USA
   6.1  Introduction: assessment of ocular blood flow ......... 163
   6.2  Assessing blood flow using Doppler imaging and
        scanning laser ophthalmoscope ......................... 164
   6.3  Further methods for assessing ocular blood flow ....... 168
   6.4  Recent and emerging techniques for assessing ocular
        blood flow ............................................ 173
   6.5  Association of ocular blood flow with ophthalmic 
        disease ............................................... 174
   6.6  Conclusion ............................................ 177
   6.7  References ............................................ 177

7  Intravascular magnetic resonance imaging (MRI) ............. 186
   V. Acikel and E. Atalar, Bilkent University, Tьrkey
   7.1  Introduction .......................................... 186
   7.2  Intravascular magnetic resonance (MR) operations ...... 187
   7.3  Catheter visualization ................................ 197
   7.4  Tracking using intravascular MR coils ................. 205
   7.5  Signal-to-noise ratio (SNR) performance of catheter
        coils ................................................. 207
   7.6  Safety of intravascular catheters ..................... 207
   7.7  Conclusion ............................................ 209
   7.8  References ............................................ 209
   
8  Cardiovascular magnetic resonance imaging (MRI) ............ 214
   R.M. Botnar, King's College London, UK and M.R. Makowski,
   King's College London, UK and Charité University of 
   Medicine, Germany
   8.1  Introduction .......................................... 214
   8.2  Biology of atherosclerosis ............................ 215
   8.3  Principles of cardiovascular magnetic resonance
        (MR) imaging .......................................... 217
   8.4  Preclinical molecular imaging in atherosclerosis ...... 224
   8.5  Clinical imaging of atherosclerosis ................... 225
   8.6  Conclusion and future trends .......................... 229
   8.7  References ............................................ 230

9  Imaging methods for detection of joint degeneration ........ 235
   T. Thote, S. Moran, A. Lin, N.J. Willett, R.E.  Guldberg,
   Georgia Institute of Technology, USA and C.P. Neu,
   Purdue University, USA
   9.1  Introduction .......................................... 235
   9.2  An overview of osteoarthritis ......................... 236
   9.3  Magnetic resonance imaging (MRI) ...................... 239
   9.4  Computer tomography (CT) based imaging ................ 244
   9.5  Ultrasound imaging for cartilage ...................... 252
   9.6  Vascular imaging ...................................... 253
   9.7  Other imaging modalities .............................. 255
   9.8  Conclusion ............................................ 257
   9.9  References ............................................ 258

10 Whole body magnetic resonance imaging (MRI) ................ 266
   C.L. Hoad, L. Marciani, S.T. Francis and
   P.A. Gowland, University of Nottingham, UK
   10.1 Introduction .......................................... 266
   10.2 Gastrointestinal (GI) magnetic resonance imaging
        (MRI) ................................................. 267
   10.3 Liver imaging ......................................... 273
   10.4 Kidney imaging ........................................ 281
   10.5 Foetal and placental imaging .......................... 288
   10.6 Conclusion ............................................ 290
   10.7 Sources of further information and advice ............. 291
   10.8 References ............................................ 291
   
   Index ...................................................... 307


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