Contributors .................................................. vii
Preface ........................................................ ix
SECTION 1 FORCES GOVERNING EXCHANGEABLE INTERACTIONS ........... 1
1 van der Waals Interactions and the Hydrophobic Effect ........ 3
Bruce C. Gibb
2 Ionic, Hydrogen Bond, and it -Cation Interactions ........... 19
Hector Adam Velazquez and Donald Hamelberg
3 Covalent Interactions in Chemosensor Design ................. 25
Yunfeng Cheng, Xiaochuan Yang, and Binghe Wang
4 Metal Chelation Chemistry ................................... 41
Dongwhan Lee
SECTION 2 STRATEGIES TOWARD BUILDING THE DESIRED BINDING
MOIETY ......................................................... 65
5 Scaffold Design Using Computational Chemistry ............... 69
Dale Drueckhammer
6 Combinatorial Search of Sensors ............................. 87
Marc Vendrell, Suihan Feng, and Young-Tae Chang
7 Molecular Imprinting and Sensor Development ................ 107
Yagang Zhang and Ken D. Shimizu
8 Dendrimer-Based Sensors .................................... 121
Lin Pu
9 Nanoparticles and Sensors .................................. 163
Yi-Cheun Yeh, Sarit S. Agasti, Krishnendu Saha, and
Vincent M. Rotello
10 Aptamer Selection, Phage Display, and Sensor Development ... 191
Hui Wang, Yan Chen, and Weihong Tan
11 Sensor Development Using Existing Scaffolds ................ 211
Hiroyasu Yamaguchi, Tomoki Ogoshi, and Akira Harada
SECTION 3 DETECTION METHODS IN CHEMOSENSING .................. 227
12 Fluorescent Detection Principles and Strategies ............ 229
Raman Parkesh, Emma B. Veale, and Thorfinnur Gunnlaugsson
13 New Fluorophore Design ..................................... 253
Michael D. Heagy
14 Colorimetric Sensor Design ................................. 275
Kevin L. Bicker, Sheryl L. Wiskur, and John J. Lavigne
15 Electrochemical Detection .................................. 297
Simon R. Bayly, George Z. Chen, and Paul D. Beer
16 Surface Plasmon Resonance and Quartz Crystal Microbalance
Methods for Detection of Molecular Interactions ............ 329
Yang Liu, Archana Jaiswal, Mark A. Poggi, and W. David
Wilson
17 Array-Based Sensors ........................................ 345
Pavel Anzenbacher Jr. and Manuel A. Palacios
SECTION 4 CHEMOSENSORS: CASE STUDffiS ........................ 369
18 Design of Cation-Selective Synthetic Fluorescent
Indicators ................................................. 371
Christoph J. Fahrni
19 Anion Sensors .............................................. 395
Philip A. Gale and Claudia Caltagirone
20 Chemosensors: Case Studies of Indicators for Organic
Molecules .................................................. 429
Oleksandr Rusin, Jorge O. Escobedo, and Robert M. Strongin
21 Molecular Recognition Elements for Toxin and Pathogen
Detection .................................................. 455
Daniel M. Lewallen, Duane M. Hatch, and Suri S. Iyer
22 Chemical Sensing and Detection in Forensic Science ......... 475
Simon W. Lewis
Index ......................................................... 497
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