The handbook of metabonomics and metabolomics / ed. by J.C.Lindon, J.K.Nicholson, E.Holmes. - Amsterdam; Oxford: Elsevier, 2007. - x, 561 p.: ill. (some col.). - Incl. bibl. ref. - Ind.: p.557-561. - ISBN 0-444-52841-5  Место хранения:   063 | Библиотека по химическим аспектам охраны окружающей среды при Институте органической химии им. Н.Н.Ворожцова. | Новосибирск

Оглавление / Contents

Foreword ....................................................... vii Sir Richard B. Sykes FRS Preface ......................................................... ix John C. Lindon, Jeremy K. Nicholson and Elaine Holmes 1 Metabonomics and Metabolomics Techniques and Their Applications in Mammalian Systems ............................. 1 Jeremy K. Nicholson, Elaine Holmes and John C. Lindon 2 Cellular Metabolomics: The Quest for Pathway Structure ....... 35 Oliver Fiehn 3 NMR Spectroscopy Techniques for Application to Metabonomics .. 55 Hans Senn and Goetz Schlotterbeck 4 High-Resolution Magic Angle Spinning NMR Spectroscopy ....... 113 Jin-Hong Chen and Samuel Singer 5 Chromatographic and Electrophoretic Separations Combined with Mass Spectrometry for Metabonomics ..................... 149 Ian D. Wilson 6 Chemometrics Techniques for Metabonomics .................... 171 Johan Trygg and Torbjцrn Lundstedt 7 Non-linear Methods for the Analysis of Metabolic Profiles ... 201 Timothy M.D. Ebbels 8 Databases and Standardisation of Reporting Methods for Metabolic Studies ........................................... 227 Susanna A. Sansone, Michael D. Waters and Mark R. Viant 9 Metabonomics in Preclinical Pharmaceutical Discovery and Development ................................................. 241 Donald G. Robertson, Michael D. Reily and Glenn H. Cantor 10 Applications of Metabonomics in Clinical Pharmaceutical R&D ......................................................... 279 Jeremy R. Everett 11 Exploiting the Potential of Metabonomics in Large Population Studies: Three Venues ............................ 289 Burton H. Singer, Jürg Utzinger, Carol D. Ryff, Yulan Wang and Elaine Holmes 12 Metabolite Profiling and Cardiovascular Disease ............. 327 David J. Grainger 13 The Role of NMR-based Metabolomics in Cancer ................ 345 Leo L. Cheng and Ute Pohl 14 NMR Spectroscopy of Body Fluids as a Metabolomics Approach to Inborn Errors of Metabolism ..................... 375 Udo F. H. Engelke, Marlies Oostendorp and Ron A. Wevers 15 A Survey of Metabonomics Approaches for Disease Characterisation ............................................ 413 John C. Lindon and Elaine Holmes 16 Metabolic Profiling: Applications in Plant Science .......... 443 Richard N. Trethewey and Arno J. Krotzky 17 In vivo NMR Applications of Metabonomics .................... 489 Dieter Leibfritz, Wolfgang Dreher and Wieland Willker 18 Applications of Metabonomics Within Environmental Toxicology .................................................. 517 Julian L. Griffin and Richard F. Shore 19 Global Systems Biology Through Integration of "Omics" Results ..................................................... 533 John C. Lindon, Elaine Holmes and Jeremy K. Nicholson Index .......................................................... 557